How Do I Know if I Need to Start Taking Zoloft Again

Brand name: Zoloft®

  • Tablets: 25 mg, 50 mg, 100 mg
  • Liquid: 20 mg/mL


Generic name: sertraline (SER tra leen)

All FDA black box warnings are at the end of this fact sheet. Please review before taking this medication.

What Is Sertraline And What Does It Care for?

Sertraline is an antidepressant medication that works in the encephalon. It is canonical for the treatment of major depressive disorder (MDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder. Information technology is as well canonical to care for obsessive-compulsive disorder (OCD) in adults, children and adolescents aged vi-17 years.

Symptoms of low include:

  • Depressed mood - feeling sad, empty, or tearful
  • Feeling worthless, guilty, hopeless, and helpless
  • Loss of involvement or pleasance in your usual activities
  • Sleep and consume more than or less than usual (for most people it is less)
  • Low energy, trouble concentrating, or thoughts of death (suicidal thinking)
  • Psychomotor agitation ('nervous free energy')
  • Psychomotor retardation (feeling like you are moving and thinking in slow motility)
  • Suicidal thoughts or behaviors


PTSD occurs when a person experiences a traumatic consequence (e.g., assault, combat experience) and and so later feels on edge; avoids situations that remind them of the issue; and experiences flashbacks or nightmares.

PMDD is a condition where a adult female experiences depression, tension, and irritability for a few days prior to menstruation that end when menstruation begins. These symptoms are more severe than those of premenstrual syndrome (PMS).

Panic Disorder occurs when a person experiences unexpected and repeated episodes of intense fear. These episodes accept physical symptoms including chest pain, shortness of jiff, heart palpitations, sweating, dizziness, and nausea. Fear of future episodes is also part of panic disorder.

Obsessive Compulsive Disorder (OCD) occurs when a person experiences the following symptoms at the same time:

  • Obsessions (unwanted, recurrent, and disturbing thoughts)
  • Compulsions (repetitive, ritualized behaviors that the person feels driven to perform in order to lessen the anxiety produced by the obsessions)


Social phobia/social feet disorder is a fright of situations where one may experience as if they are existence judged past others. Symptoms include:

  • Blushing
  • Difficulty talking
  • Nausea
  • Sweating
  • Shaking


Sertraline may besides exist helpful when prescribed "off-label" for binge-eating disorder, bulimia nervosa, and generalized feet disorder (GAD). "Off-label" means that it hasn't been approved by the Food and Drug Assistants for this condition. Your mental health provider should justify his or her thinking in recommending any "off-label" treatment. They should be clear about the limits of the research around that medication and if at that place are any other options.

What Is The Nigh Important Information I Should Know Most Sertraline?

Do non stop taking sertraline, even when you experience better. With input from you, your wellness care provider will assess how long you will need to have the medicine.

Missing doses of sertraline may increase your run a risk for relapse in your symptoms.

Stopping sertraline abruptly may result in 1 or more of the following withdrawal symptoms: irritability, nausea, feeling silly, vomiting, nightmares, headache, and/or paresthesias (prickling, tingling sensation on the skin).

Depression is likewise a role of bipolar affliction. People with bipolar disorder who take antidepressants may be at risk for "switching" from low into mania. Symptoms of mania include "high" or irritable mood, very high self-esteem, decreased need for slumber, pressure to keep talking, racing thoughts, being easily distracted, frequently involved in activities with a big risk for bad consequences (for example, excessive buying sprees).

Medical attention should be sought if serotonin syndrome is suspected. Please refer to serious side effects for signs/symptoms.

Are At that place Specific Concerns Well-nigh Sertraline And Pregnancy?

If you are planning on becoming pregnant, notify your health care provider to all-time manage your medications. People living with MDD who wish to become pregnant face important decisions. Untreated MDD has risks to the fetus, likewise equally the mother. Information technology is important to talk over the risks and benefits of treatment with your medico and caregivers. For women who take antidepressant medications during weeks 13 through the cease of their pregnancy (second and third trimesters), in that location is a risk that the baby can exist built-in before it is fully developed (before 37 weeks).

For mothers who take taken SSRIs during their pregnancy, at that place appears to be less than a 1% chance of infants developing persistent pulmonary hypertension. This is a potentially fatal status that is associated with utilise of the antidepressant in the 2d half of pregnancy. Nonetheless, women who discontinued antidepressant therapy were five times more probable to accept a depression relapse than those who continued their antidepressant. If you are pregnant, please talk over the risks and benefits of antidepressant apply with your health intendance provider.

Circumspection is brash with breastfeeding since sertraline does laissez passer into breast milk.

What Should I Discuss With My Wellness Care Provider Earlier Taking Sertraline?

  • Symptoms of your condition that bother you the virtually
  • If you accept thoughts of suicide or harming yourself
  • Medications yous have taken in the past for your condition, whether they were constructive or caused any adverse effects
  • If you feel side furnishings from your medications, discuss them with your provider. Some side effects may pass with time, just others may require changes in the medication.
  • Any other psychiatric or medical problems you have, including a history of bipolar disorder
  • All other medications you are currently taking (including over the counter products, herbal and nutritional supplements) and any medication allergies you have
  • Other non-medication treatment you lot are receiving, such as talk therapy or substance abuse treatment. Your provider can explicate how these different treatments piece of work with the medication.
  • If yous are meaning, plan to become significant, or are breastfeeding
  • If you drink alcohol or utilise drugs


How Should I Take Sertraline?

Sertraline is usually taken 1 fourth dimension per day with or without food.

Typically patients begin at a low dose of medicine and the dose is increased slowly over several weeks.

The dose usually ranges from 50 mg to 200 mg. Simply your health care provider tin determine the correct dose for you.

If you are taking information technology for PMDD, sertraline can exist taken once daily (everyday) or intermittently (ordinarily starting 14 days prior to menstruation through the first full twenty-four hours of menses of each bike).

The liquid should be measured with an oral syringe or dropper which you can get from your pharmacy. It should be added to 4 ounces of water, ginger ale, lemon/lime soda, lemonade, or orange juice immediately prior to taking the medication. It should non be mixed in accelerate.

Consider using a calendar, pillbox, alarm clock, or jail cell telephone alert to help yous recollect to have your medication. You may also ask a family member or friend to remind you or check in with yous to be sure you are taking your medication.

What Happens If I Miss A Dose Of Sertraline?

If you miss a dose of sertraline, accept it equally soon as yous remember, unless information technology is closer to the time of your adjacent dose. Hash out this with your wellness care provider. Do not double your next dose or have more than what is prescribed.

What Should I Avoid While Taking Sertraline?

Avoid drinking alcohol or using illegal drugs while you are taking antidepressant medications. They may subtract the benefits (e.thousand., worsen your condition) and increase adverse effects (e.grand., sedation) of the medication.

What Happens If I Overdose With Sertraline?

If an overdose occurs, telephone call your doctor or 911. Yous may demand urgent medical care. You may as well contact the poison command center at one-800-222-1222.

A specific treatment to reverse the effects of sertraline does non exist.

What Are The Possible Side Effects Of Sertraline?

Common side effects

  • Headache, nausea, diarrhea, dry mouth, increased sweating
  • Feeling nervous, restless, drawn, sleepy or having trouble sleeping (insomnia)

These will often improve over the outset week or ii every bit you keep to take the medication.

Sexual side effects, such equally issues with orgasm or ejaculatory delay oft exercise not diminish over time.

Rare/serious side effects

Low sodium blood levels (symptoms of low sodium levels may include headache, weakness, difficulty concentrating and remembering), teeth grinding, bending closure glaucoma (symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye).

Serotonin syndrome (symptoms may include shivering, diarrhea, defoliation, severe muscle tightness, fever, seizures, and death), seizure

SSRI antidepressants including sertraline may increase the risk of bleeding events. Combined use of aspirin, nonsteroidal anti-inflammatory drugs (due east.thou., ibuprofen, naproxen), warfarin, and other anti-coagulants may increase this hazard. This may include gums that bleed more easily, olfactory organ drain, or gastrointestinal bleeding. Some cases have been life threatening.

Are In that location Any Risks For Taking Sertraline For Long Periods Of Time?

To date, there are no known issues associated with long term use of sertraline. It is a safe and effective medication when used as directed.

What Other Medications May Interact With Sertraline?

Sertraline should non be taken with or within two weeks of taking monoamine oxidase inhibitors (MAOIs). These include phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), rasagiline (Azilect®), and selegiline (Emsam®).

Although rare, at that place is an increased risk of serotonin syndrome when sertraline is used with other medications that increase serotonin, such as other antidepressants, migraine medications called "triptans" (e.yard., Imitrex®), some pain medications (e.g., tramadol (Ultram®)), and the antibiotic linezolid (Zyvox®).

Sertraline should not exist taken with pimozide (Orap®).

Sertraline may increment the furnishings of other medications that can cause haemorrhage (east.m., ibuprofen (Advil®, Motrin®), warfarin (Coumadin®) and aspirin).

Sertraline liquid should NOT exist taken in combination with disulfiram (Antabuse®) due to the booze content of the concentrate.

How Long Does It Take For Sertraline To Work?

Sleep, free energy, or ambition may testify some improvement within the start ane-2 weeks. Improvement in these concrete symptoms tin can be an important early on signal that the medication is working. Depressed mood and lack of interest in activities may demand up to 6-8 weeks to fully ameliorate.

Summary of FDA Black Box Warnings

Suicidal thoughts or deportment in children and adults

Depression and certain other psychiatric disorders are themselves associated with increases in the chance of suicide. Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in beliefs, whether or not they are taking antidepressant medications. This risk may persist until significant remission occurs.

In curt-term studies, antidepressants increased the risk of suicidality in children, adolescents, and immature adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults across age 24. Adults historic period 65 and older taking antidepressants have a decreased risk of suicidality. Patients, their families, and caregivers should be alert to the emergence of feet, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient'due south prescriber or health intendance professional. All patients beingness treated with antidepressants for whatever indication should watch for and notify their health care provider for worsening symptoms, suicidality and unusual changes in beliefs, especially during the first few months of treatment.

Provided past

(December 2020)

©2020 The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Illness (NAMI). CPNP and NAMI make this certificate available under the Creative Eatables Attribution-No Derivatives iv.0 International License. Concluding Updated: January 2016.

This data is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. This information is for educational and informational purposes simply and is not medical advice. This information contains a summary of important points and is non an exhaustive review of information about the medication. Always seek the advice of a doctor or other qualified medical professional with any questions yous may take regarding medications or medical weather condition. Never delay seeking professional medical advice or condone medical professional advice every bit a result of any data provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims whatever and all liability alleged as a result of the data provided herein.

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Source: https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Sertraline-(Zoloft)

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